Endocrine Abstracts

The control of the onset of human puberty remains an enigma. According to current understanding, the ‘GnRH pulse generator’, a functionally interconnected and synchronized network of GnRH neurons, is inhibited throughout childhood following a period of pubertal level activity during fetal life. Release of this inhibition at the early second decade of life signifies the reawakening of the pulse generator.Recently, we have identified loss-of-func...

Aims: To document clinical associations of perceived well-being (PWB) in obese subjectsMethods: Prospectively collected ‘Obesity Polyclinic’ database was retrospectively analyzed for the answers of the questionnaries fullfilled during the initial evaluation for obesity. After exclusion unavailable cases, the answers to the question ‘how do you describe your general health/well-being? i) very well ii) well iii) <e...

Objective: The aim of this single centre prospective open trial was to evaluate the long-term efficacy of octreotide LAR in acromegaly patients and possibility of withdrawal of this therapy.Methods: In total 17 patients with acromegaly diagnosed at Endocrinology Clinic in Sarajevo, somatostatin sensitive (ten females and six males, age range 37–65 years, six patients with microadenoma and ten patients with macroadenoma) were treated with octreotide....

Background: Although a number of studies show that the serum levels of antithyroid peroxidase antibodies (TPO-Ab) in patients with Hashimoto’s thyroiditis decline during levothyroxine treatment, only a few provide quantitative data. The objective of the present study was to provide this information.Methods: This was a retrospective study of TPO-Ab concentrations in 44 women and 4 men (median age 45.5 years; range 17–76 years) with Hashimoto&#14...

Background: In polycystic ovary syndrome (PCOS), in response to stimulation by luteinizing hormone (LH), the ovarian theca cell synthesizes androgens. However, associations of serum androgen levels with metabolic parameters yet to be determined. We aimed to investigate these associations.Methods: We retrospectively evaluated our outpatient admission records for PCOS, hirsutism, oligomenorrhea, or secondary amenorrhea. PCOS diagnosis was made after exclud...

Introduction: Synchronous and asynchronous cases of acromegaly and other malignancies have been reported in literature. However, synchronous apperance of acromegaly and gastrointestinal stromal tumors (GIST) is encountered so rarely. We herein reported a case of synchronous acromegaly and GIST.Case report: A 59-year-old patient was investigated due to iron deficiency anemia. On the physical examination revealed enlarged hands and coarse facial feature; a...

Introduction: Adolescence is a crucial period for linear growth, and sports training during this time may have positive or negative effects on some physiological processes as growth. The purpose of this study was to evaluate the effect of intense training during somatic growth on the onset of puberty and growth development in adolescent wrestlers.Description of methods/design: Fifty adolescent male wrestlers and 21 sedentary healthy male controls aged 13...

Background: Diagnosis of primary hyperparathyroidism (PHP) is sometimes challenging and needs supportive evidence. We aimed to document laboratory findings (ratio of calcium clearance to creatinine clearance, ratio of phosphorus clearance to creatinine clearance, serum chloride to phosphorus ratio, serum alkaline phosphatase) and thyroid pathologies associated with established PHP that may provide supplementary clues to the diagnosis.Methods: We document...

Background and aim: Wrestling success depends on power, power endurance, and maximum strength, muscular endurance of short duration, flexibility as well as technique and tactical skills. Weight control and weight loss are also very important issues in the view of wrestling success. In this study, it was aimed to investigate the anthropometric features, serum lipoproteins, glucose homeostasis and leptin levels in Turkish National Senior Wrestlers and healthy sedentary males.</p...

Plant growth factors are used commonly in agriculture. The effect of these factors on human health is unknown. Gibberellins are the most commonly used growth factors that have the structure of Diterpenoid acid. One of the gibberellins (GA3) induces tumor formation in mice but the mechanism of action is not known. We here examined changes in levels of GH and IGF-1 and examined whether there is a correlation between growth factors’ levels and weight changes.<p class="ab...